advances in gene/gene-editing-based therapies for Acute Myeloid Leukemia

photorealistic molecular visualization—now ready to view.

This scene illustrates CRISPR/Cas9-mediated gene editing in an AML cell:

• The foreground shows a leukemic cell with a rough, abnormal surface, harboring mutated genes (e.g., FLT3, NPM1, IDH1/2) in its genome—represented by DNA double helices.

• Above, a Cas9 nuclease complexed with guide RNA is poised for editing, demonstrating recognition and targeting of the mutant sequence.

• Below, edited hematopoietic stem/progenitor cells with a healthy, smooth appearance are producing normal, functioning blood cells.